Response-adaptive designs in clinical trials for targeting the best treatment: an overview
Response-adaptive designs are increasingly being implemented in clinical trials, particularly early phase trials, and they have increasingly stimulated the work of researchers. This paper reviews a particular class of response-adaptive designs, which have a different property from the most adaptive designs in literature. These are response-adaptive designs targeting asymptotically the superior response, that is, treating with the superior treatment with prob- ability converging to one. The model underlying such designs is a randomly reinforced urn. In the context of clinical trials, this property is particularly attractive from an ethical point of view. This overview starts from the early paper of  until the recent work by .